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Rosalind Franklin: Photo 51, X-Ray Crystallography & DNA Structure

Encyclopedia/1. The Cosmos & The Natural World/6. Medicine & Human Biology/07. Medical & Health Biographies  •  Curated by Admin Timeline.sg

Timeline of Rosalind Franklin (1920-1958), the physical chemist and X-ray crystallographer whose work was crucial to understanding DNA structure, and her lasting legacy in science.

Chronological Storyline (39 Milestones)

Jul 25, 1920 CE

Birth in London

Rosalind Elsie Franklin is born to a wealthy Jewish family in Notting Hill, London. She will later become a pioneer in X-ray crystallography. #science #womeninscience

Birth in London
Birth in London
By MRC Laboratory of Molecular Biology - This file was derived from: Rosalind Franklin.jpg:, CC BY-SA 4.0, https://commons.wikimedia.org/w/index.php?curid=77075413
Sep 1, 1926 CE

Attends Norland Place School

Franklin begins her education at Norland Place School in London, showing early aptitude for science and mathematics. #education #science

Attends Norland Place School
Attends Norland Place School
By Norland Place - Norland Place School, CC BY-SA 4.0, https://commons.wikimedia.org/w/index.php?curid=93237055
Sep 1, 1931 CE

Enters St Paul's Girls' School

Franklin earns a scholarship to St Paul's Girls' School, where she excels in science and languages, winning a school science prize in 1936. #education #womeninscience

Enters St Paul's Girls' School
Enters St Paul's Girls' School
By Chmee2 - Own work, CC BY-SA 3.0, https://commons.wikimedia.org/w/index.php?curid=25505761
Oct 1, 1938 CE

Begins Studies at Newnham College, Cambridge

Franklin enrolls at Newnham College, Cambridge, to study natural sciences, specializing in physical chemistry. #education #science

Begins Studies at Newnham College, Cambridge
Begins Studies at Newnham College, Cambridge
By Cmglee - Own work, CC BY-SA 3.0, https://commons.wikimedia.org/w/index.php?curid=32161742
Jun 1, 1941 CE

Graduates with First-Class BA

Franklin graduates with a first-class BA in physical chemistry from Cambridge, but she is not awarded a full degree because women were not then eligible. #science #history

Aug 1, 1942 CE

Begins Research at BCURA

Franklin joins the British Coal Utilisation Research Association (BCURA) during World War II, studying the porosity of coal to improve gas masks. #science #wwii

Aug 1, 1945 CE

Awarded PhD from Cambridge

Franklin is awarded a PhD in physical chemistry for her thesis on the micromeritics of coal, based on her BCURA research. #science #education

Feb 1, 1946 CE

Publishes First Major Paper on Coal

Franklin publishes a paper on the structure of coal in Transactions of the Faraday Society, establishing her reputation in physical chemistry. #science #chemistry

Jan 1, 1947 CE

Moves to Paris for X-Ray Crystallography

Franklin takes a position at the Laboratoire Central des Services Chimiques de l'État in Paris, where she learns X-ray crystallography techniques under Jacques Mering. #science #crystallography

Jun 1, 1948 CE

Publishes Work on Carbon Structure

Franklin publishes a seminal paper on structural changes in carbons upon heat treatment, providing insights into graphitization. #science #chemistry

Feb 1, 1950 CE

Influential Paper on Coal Microporosity

Franklin's work on the microporosity of coals becomes a key reference in coal science, demonstrating her skill in physical chemistry. #science #chemistry

Jan 1, 1951 CE

Appointed at King's College London

Franklin is appointed as a research associate at King's College London's MRC Biophysics Unit, tasked with applying X-ray diffraction to DNA. #science #DNA

Appointed at King's College London
Appointed at King's College London
By Hogweard - Arms of King's College London.svg King's College, London arms.svg, Public domain, https://commons.wikimedia.org/w/index.php?curid=125206690
Nov 21, 1951 CE

Seminar on DNA X-Ray Diffraction

Franklin presents a seminar on her initial DNA X-ray diffraction data, but James Watson misremembers and underestimates her work. #science #DNA

May 6, 1952 CE

Captures Photo 51

Franklin and graduate student Raymond Gosling capture the iconic X-ray diffraction image Photo 51, revealing the B form of DNA with a helical structure. #science #DNA #photo51

Captures Photo 51
Captures Photo 51
By Raymond Gosling - King's College London Archives: KDBP1/1/867. Taken from "The double helix: “Photo 51” revisited" by Thoru Pederson (https://doi.org/10.1096/fj.202000119), PD, https://en.wikipedia.org/w/index.php?curid=38068629
Nov 1, 1952 CE

Completes Analysis of DNA A-Form

Franklin carefully analyzes and indexes the diffraction pattern of the A form of DNA, deducing its space group and symmetry. #science #DNA

Jan 28, 1953 CE

Records B-Form Helical Parameters

Franklin notes in her lab book that the B form of DNA is a helix with a specific diameter and pitch, contradicting earlier models. #science #DNA

Feb 28, 1953 CE

Wilkins Shows Photo 51 to Watson

Without Franklin's knowledge, Maurice Wilkins shows Photo 51 to James Watson, who immediately recognizes the helical structure, catalyzing the double helix model. #science #DNA

Apr 25, 1953 CE

Watson and Crick Publish DNA Double Helix Model

Francis Crick and James Watson publish the double helix model of DNA in Nature, citing Franklin's data and acknowledging her contribution. #science #DNA

Watson and Crick Publish DNA Double Helix Model
Watson and Crick Publish DNA Double Helix Model
By 84user adapting file originally uploaded by Richard Wheeler (Zephyris) at en.wikipedia - Derived from File:DNA orbit animated.gif originally from here., CC BY-SA 3.0, https://commons.wikimedia.org/w/index.php?curid=6285050
Jul 1, 1953 CE

Moves to Birkbeck College

Franklin leaves King's College London and joins Birkbeck College, where she shifts focus to the Tobacco Mosaic Virus (TMV). #science #career

Moves to Birkbeck College
Moves to Birkbeck College
By Robin S. Taylor - Own work, with helmet by Sodacan, CC BY-SA 4.0, https://commons.wikimedia.org/w/index.php?curid=80107375
Aug 1, 1953 CE

Publishes DNA Papers in Nature

Franklin and Gosling publish two companion papers in Nature describing X-ray diffraction of both A and B forms of DNA, providing key evidence for the double helix. #science #DNA

Oct 1, 1953 CE

Begins TMV Research at Birkbeck

Franklin starts her research on Tobacco Mosaic Virus, applying her crystallography skills to understand virus structure. #science #virology

Begins TMV Research at Birkbeck
Begins TMV Research at Birkbeck
By Unknown author - [1], Public domain, https://commons.wikimedia.org/w/index.php?curid=3430584
Mar 1, 1954 CE

Obtains First TMV Diffraction Pattern

Franklin successfully obtains the first X-ray diffraction pattern of Tobacco Mosaic Virus, confirming its helical structure. #science #virology

Jun 1, 1955 CE

Publishes TMV Structure Paper

Franklin publishes a major paper on the structure of Tobacco Mosaic Virus, showing the helical arrangement of protein subunits and RNA. #science #virology

Sep 1, 1956 CE

Diagnosed with Ovarian Cancer

Franklin is diagnosed with ovarian cancer, possibly linked to radiation exposure. She undergoes surgery and treatment. #science #health

Mar 20, 1957 CE

Returns to Research After Surgery

Franklin returns to her research at Birkbeck after surgery, continuing her work on TMV with a small team. #science #perseverance

Feb 1, 1958 CE

Publishes Final TMV Paper with Klug

Franklin and Aaron Klug publish a paper on the structure of TMV, marking her last major contribution before her death. #science #virology

Apr 16, 1958 CE

Death in London

Rosalind Franklin dies at age 37 in Chelsea, London, due to complications from ovarian cancer. #science #history

Dec 10, 1962 CE

Nobel Prize Awarded to Watson, Crick, Wilkins

The Nobel Prize in Physiology or Medicine is awarded to James Watson, Francis Crick, and Maurice Wilkins for the structure of DNA. Franklin, who died in 1958, is not eligible. #science #DNA #nobel

Feb 25, 1968 CE

Watson Publishes 'The Double Helix'

James Watson's memoir 'The Double Helix' portrays Franklin in a negative light, sparking controversy and efforts to correct the record. #science #history #books

Aug 15, 1975 CE

Biography 'Rosalind Franklin and DNA' Published

Anne Sayre's biography 'Rosalind Franklin and DNA' provides a detailed and corrective account of Franklin's contributions. #science #books #womeninscience

Nov 15, 1982 CE

Blue Plaque Commemorates Franklin

A blue plaque is unveiled at her childhood home in London, recognizing her important scientific legacy. #history #womeninscience

Oct 1, 1992 CE

King's College Establishes Franklin Fellowship

King's College London establishes a Rosalind Franklin Research Fellowship to support women in science. #education #womeninscience

Apr 25, 2003 CE

Nature Special Issue on DNA 50th Anniversary

Nature publishes a special issue honoring the 50th anniversary of the DNA double helix, highlighting Franklin's pivotal role. #science #DNA #history

Nov 1, 2004 CE

Royal Society Creates Rosalind Franklin Award

The Royal Society establishes the Rosalind Franklin Award, recognizing contributions of women in science and supporting their careers. #science #womeninscience #award

Nov 1, 2008 CE

ExoMars Rover Named Rosalind Franklin

The European Space Agency names its ExoMars rover 'Rosalind Franklin,' honoring her contributions to science. #space #science )

ExoMars Rover Named Rosalind Franklin
ExoMars Rover Named Rosalind Franklin
By Photograph by Mike Peel (www.mikepeel.net). - Own work, CC BY-SA 4.0, https://commons.wikimedia.org/w/index.php?curid=177261072
Mar 1, 2012 CE

Royal Mail Stamp Featuring Franklin

The UK Royal Mail issues a stamp featuring Rosalind Franklin as part of its 'Women of Achievement' series. #history #science

Jul 25, 2015 CE

Statue of Franklin Unveiled at King's College

A statue of Rosalind Franklin is unveiled at King's College London, ensuring her legacy remains visible. #history #science #womeninscience

Jul 25, 2020 CE

Google Doodle for 100th Birthday

Google commemorates Rosalind Franklin's 100th birthday with a Doodle highlighting her DNA discovery. #science #DNA #womeninscience

Sep 1, 2022 CE

ExoMars Rover Begins Journey (Delayed)

The ExoMars rover 'Rosalind Franklin' begins its delayed mission to search for signs of past life on Mars, carrying her name into space. #space #science )