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1.5.1.1 Genetic Intervention

Encyclopedia/1. The Cosmos & The Natural World/5. Life Sciences/01. Evolutionary Developmental Biology  •  Curated by Admin Timeline.sg

Chronological Storyline (12 Milestones)

8000 BCE

Domestication by selective breeding

Early farmers unknowingly practise genetic selection, transforming wild teosinte into maize and wolves into dogs. Source — Wikipedia:

1866 CE

Mendel’s laws of inheritance

Gregor Mendel’s pea experiments reveal the basic rules of heredity, founding genetics. Source — Wikipedia:

1876 CE

Germ theory applied to medicine

Robert Koch and Louis Pasteur establish that specific microbes cause specific diseases, transforming health practice. Source — Wikipedia:

1953 CE

Structure of DNA

Watson, Crick, Franklin and Wilkins reveal DNA’s double helix, explaining how genes are copied. Source — Wikipedia:

1968 CE

Green Revolution high-yield grains

Norman Borlaug’s semi-dwarf wheat, adopted across Mexico, India and Pakistan, averts mass famine. Source — Wikipedia:

1973 CE

Recombinant DNA

Cohen and Boyer splice genes between organisms, launching genetic engineering and biotechnology. Source — Wikipedia:

1973 CE

Yuan Longping’s hybrid rice

Chinese agronomist Yuan Longping develops high-yield hybrid rice that greatly boosts food security in Asia. Source — Wikipedia:

1996 CE

Dolly the cloned sheep

Dolly becomes the first mammal cloned from an adult cell, proving somatic cells can be reprogrammed. Source — Wikipedia: )

2003 CE

Human Genome Project completed

An international consortium finishes sequencing the human genome, opening the genomic era of medicine. Source — Wikipedia:

2010 CE

Synthetic life & synthetic biology

The J. Craig Venter Institute builds a cell controlled by a chemically synthesised genome. Source — Wikipedia:

2012 CE

CRISPR-Cas9 gene editing

Doudna and Charpentier turn bacterial CRISPR into a precise, programmable gene-editing tool (Nobel, 2020). Source — Wikipedia:

Video
Video
2018 CE

First CRISPR-edited babies

Chinese scientist He Jiankui announces gene-edited infants, igniting a global bioethics reckoning. Source — Wikipedia: